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Pathophysiological and Biomechanical Considerations Stage 3 wounds are characterized by: Deep tissue deformation and necrosis Elevated protease activity (MMP imbalance) Increased bacterial colonization and biofilm formation Dressings must therefore target: Exudate Control Prevent maceration and protease accumulation Debridement Support Facilitate autolysis (alginate/hydrofiber) Bioburden Reduction Antimicrobial modulation when indicated Notably, variability in dressing composition and performance is a recognized limitation due to a lack of uniform testing frameworks

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