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For apoptosis studies
Smiles: CC1C=NC(CN2C=NC3=C(Cl)N=C(N)N=C23)=C(C)C=1OC
Discovery of a Novel Dual Histone Deacetylases (HDACs) and Mammalian Target of Rapamycin (mTOR) Target Inhibitor as a Promising Strategy for Cancer Therapy
InChi: InChI=1S/C27H20N4O2S/c32-25(30-27-29-12-13-34-27)24(17-4-2-1-3-5-17)31-16-21-7-6-19(15-22(21)26(31)33)18-8-9-23-20(14-18)10-11-28-23/h1-15
Smiles: CC1(C)CCC[C@]2(C)[C@@H]1CC[C@@]13C[C@](O)(CO)[C@@H](C1)CC[C@@H]23
JAK1-IN-4 uinol A For apoptosis studiesJAK1 IN 4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12. 8 M and >30 M for JAK1, JAK2, and JAK3, respectively. JAK1 IN 4 inhibits STAT3 phosphorylation in NCI H 1975 cells (IC50, 227 nM). Product information CAS Number: 2091134 35 7 Molecular Weight: 521. 59 Formula: C26H32FN9O2 Chemical Name: (2R) 2 [(3R) 3,4 dimethylpiperazin 1 yl] N (3 {5 fluoro 2 [(3 methoxy 1 methyl 1H pyrazol 4 yl)amino]pyrimidin 4 yl} 1H indol 7