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This works specifically, whenever you cast instants or spells on a creature you control, allowing you to exile the card after resolving it, instead of putting it in your graveyard to then be put back into your hand on the next end step

But not knowing whether or not something is going to die

This is a strategy as old as time, but it has had its struggles in Duel Commander recently

(Bevy of Beebles), whose loyalty is equal to the number of Beebles you control and creates/sacrifices Beebles to activate its abilities, as well as Surgeon ~General~ Commander, which mentions the currently unknown mechanic mutateperhaps a preview of Magics upcoming set, Ikoria Lair of Behemoths

Just try to get an Archon of Cruelty into play and ride that to victory