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female BALB/c mice) treatment suppresses hind-paw swelling in a dose-dependent manner
CAS Number: 202471-84-9
InChiKey: VMQKWKNTSXIWGW-UHFFFAOYSA-N
untreated versus 9
294(18):7377-7387
Itraconazole-d5 oxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside female BALB/c mice) treatment suppressesItraconazole d5 (R51211 d5) is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14 demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Product information CAS
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