MAO-IN-M30 dihydrochloride rdU Carfilzomib-dependent selective inhibition of the

Carfilzomib-dependent selective inhibition of the chymotrypsin-like activity of the proteasome leads to antitumor activity in Waldenstrom's Macroglobulinemia

SB-269970A

A concentration-dependent inhibitory effect is observed with IC50 of 454 nM

86±33 μM

resulting in inhibition of cell growth and apoptosis

MAO-IN-M30 dihydrochloride rdU Carfilzomib-dependent selective inhibition of theMAO IN M30 dihydrochloride is an orally active, brain permeable, and brain selective irreversible MAO A (IC50=37 nM) and MAO B (IC50=57 nM) inhibitor. MAO IN M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO IN M30 dihydrochloride has a neuroprotective effect against Dexamethasone induced brain cell apoptosis. MAO IN M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's