Lesogaberan napadisylate - CAS# 477956-38-0 Catalog No.:M34969-C Chemical Name: 6-carbamimidoylnaphthalen-2-yl 4-carbamimidamidobenzoate

Chemical Name: 6-carbamimidoylnaphthalen-2-yl 4-carbamimidamidobenzoate

Formula: C31H32N4O3

Solubility: DMSO : 45 mg/mL (121

Smiles: [2H]C1=C(C(=O)C2=CC=C3C(CCN32)C(O)=O)C([2H])=C([2H])C([2H])=C1[2H]

Formula: C37H45Cl3N12O6

Lesogaberan napadisylate - CAS# 477956-38-0 Catalog No.:M34969-C Chemical Name: 6-carbamimidoylnaphthalen-2-yl 4-carbamimidamidobenzoateLesogaberan (AZD 3355) napadisylate is a potent and selective GABAB receptor agonist with an EC50 of 8. 6 nM for human recombinant GABAB receptors. The affinity (Kis) of Lesogaberan napadisylate for rat GABAB and GABAA receptors, as measured by displacement of [3H]GABA binding in brain membranes: 5. 1 nM and 1. 4 M, respectively. Lesogaberan napadisylate inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action.